Curative effect of second curettage for treatment of gestational trophoblastic disease - Results of the Belgian registry for gestational trophoblastic disease
نویسندگان
چکیده
Objective We assessed the curative effect of a second curettage in patients with persistent hCG serum levels after first for gestational trophoblastic disease (GTD). Study Design This prospective observational study used data Belgian register GTD between July 2012 and January 2017. analysed who underwent curettage. included 313 database. Primary endpoints were need chemotherapy. Results Thirty-seven population (12 %) 20 had human chorionic gonadotropin hormone (hCG) elevation before Of them, 9 (45 needed no further treatment afterwards. Eleven (55 Nine (82 cured single-agent chemotherapy 2 (18 multi-agent 37 patients, below 5000 IU/L undergoing without 65 % versus 45 level more than IU/L. ten 1000 IU/L, eight Conclusions Patients post-mole neoplasia can benefit from to avoid chemotherapy, especially when is lower
منابع مشابه
Gestational Trophoblastic Disease
In partial molar pregnancies, the trophoblast cells have three sets of chromosomes (triploid). Two sperm are believed to fertilise the ovum at the same time, leading to one set of maternal and two sets of paternal chromosomes. Around 10% of partial moles are tetraploid or mosaic in nature. There is usually evidence of fetal tissue or fetal blood cells in a partial molar pregnancy. An embryo may...
متن کاملGestational trophoblastic disease.
BACKGROUND Molar pregnancy represents a significant burden of disease on the spectrum of Gestational Trophoblastic Disease (GTD). The incidence appears to be quite high in South Asia. The objective of this study was to determine the frequency of GTD, and clinical presentation, management and outcome of patients with molar pregnancy. METHODS This retrospective, descriptive study was conducted ...
متن کاملGestational trophoblastic disease.
OBJECTIVE To provide standards for the diagnosis and treatment of patients with hydatidiform mole and gestational trophoblastic tumours (GTT). OPTIONS Prognostic factors useful for treatment decisions in GTT are defined with patients classified as low-, medium-, and high-risk groups. OUTCOMES Improved mortality and morbidity. EVIDENCE Evidence was gathered using Medline for relevant studi...
متن کاملGestational trophoblastic disease.
Patients diagnosed with molar pregnancy are treated by either suction curettage or hysterectomy, depending on their desire to preserve fertility. We use single-agent chemotherapy, preferably methotrexate, to treat low- or moderate-risk persistent trophoblastic tumors. High-risk patients who have metastatic disease are treated primarily with combination chemotherapy and, as indicated, adjuvant r...
متن کاملGestational Trophoblastic Disease
It is over 100 years since Felix Marchand identified choriocarcinoma as a tumor arising from placental villous trophoblast. In 1956, Hertz etal 1 first reported the cure of a patient with metastatic choriocarcinoma using chemotherapy. The next decade saw Hertz and colleagues at the National Institute of Health, Brewer in Chicago and Bagshawe in London develop the chemotherapeutic approach to ge...
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ژورنال
عنوان ژورنال: European Journal of Obstetrics & Gynecology and Reproductive Biology
سال: 2021
ISSN: ['1872-7654', '0301-2115']
DOI: https://doi.org/10.1016/j.ejogrb.2020.12.001