Cumulative cardiotoxic effect of bleomycin in experiment

The aim of the study was to evaluate cumulative toxic effect bleomycin under experimental conditions
 Material and Methods. conducted in Research Institute Transport Medicine during 2016-2021. model cardiotoxic performed using medication "Bleocin" manufactured by Nippon Kayaku Co., Ltd. (Japan). According task, on 10 mature rats both sexes Wistar line with a body weight 237 ± 20 g.
 Rats were housed standard vivarium conditions Odessa National Medical University. Animals divided into 2 groups: group (n = 5) control 5). Bleomycin animals obtained intraperitoneally at dose 0.5 IU / kg 1st 8th days. Withdrawal from experiment 5th, 14th 28th day experiment, followed morphological morphometric examination.
 material after weighing morphometry fixed neutral 10% formalin solution poured paraffin. Histological sections stained hematoxylin-eosin, MSB, Van Gizon. Performed light microscopy.
 After two weeks there decrease myocardial 7-10% baseline, pronounced dystrophic changes myocardium. Repeated administration has leading irreversible myocardium endothelial dysfunction clinically manifested heart attack, vascular pathology significant doses bleomycin. Morphofunctional right ventricle are prominent considered be pathognomic for toxicity.
 Conclusions: 1. mammals
 2. severity is proportional tissue concentration drug, which duration exposure