Cumulative and acute toxicity of repeated high-dose tobramycin treatment in cystic fibrosis
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چکیده
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Acute and Repeated Dose Toxicity Assessment of Kelussia Odoratissima Mozaff Essential Oil in Female Rat
Background: We aimed in this study to evaluate the acute and repeated dose toxicity of Kelussia odoratissima Mozaff (Kelussia) identified as a rare medicinal plant species which grows in western parts of Iran with potential nutraceutical applications. Materials and Methods: To determine the clinical, hematological, biochemical, necropsy and histopathological effects of the herb’s essential oil...
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It has been established that inhaled tobramycin has a positive effect on respiratory function in Pseudomonas-aeruginosa positive patients with cystic fibrosis (CF). In a previous study the authors reported that low-dose tobramycin preparations containing the preservative phenol caused significant bronchial obstruction. Recently, high-dose tobramycin preparations with and without preservatives/p...
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Cystic fibrosis (CF) patients receive repeated courses of aminoglycoside therapy. These patients would consequently be expected to be more susceptible to cochleotoxicity, a recognized side effect with single courses of aminoglycoside therapy. The primary aim of this retrospective study was to establish the incidence and severity of auditory deficit in CF patients. Standard (0.25- to 8-kHz) and ...
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Cystic Fibrosis (CF) is the most common lethal genetic disorder in North America and Europe. Most patients succumb to progressive lung disease characterized by an exaggerated neutrophilic inflammation. In animal models of chronic infection, high-dose ibuprofen was demonstrated to reduce inflammation without hindering bacterial clearance. This led to two clinical trials, which demonstrated a ben...
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Introduction. Antibiotic treatment regimens against Pseudomonas aeruginosa lung infection in cystic fibrosis (CF) patients often include aminoglycoside antibiotics that may cause chronic renal failure after repeated courses. Aminoaciduria is an early marker of acute aminoglycoside-induced renal tubular dysfunction. We hypothesized that urinary amino acid reabsorption is decreased after repeated...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 1987
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.31.4.594