منابع مشابه
Dynamics of Mutant Cells in Hierarchical Organized Tissues
Most tissues in multicellular organisms are maintained by continuous cell renewal processes. However, high turnover of many cells implies a large number of error-prone cell divisions. Hierarchical organized tissue structures with stem cell driven cell differentiation provide one way to prevent the accumulation of mutations, because only few stem cells are long lived. We investigate the determin...
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Identifying the molecular mechanisms underlying OL development is not only critical to furthering our knowledge of OL biology, but also has implications for understanding the pathogenesis of demyelinating diseases such as Multiple Sclerosis (MS). Cellular development is commonly studied with primary cell culture models. Primary cell culture facilitates the evaluation of a given cell type by pro...
متن کاملGenerating Primary Fibroblast Cultures from Mouse Ear and Tail Tissues.
Primary cells are derived directly from tissue and are thought to be more representative of the physiological state of cells in vivo than established cell lines. However, primary cell cultures usually have a finite life span and need to be frequently re-established. Fibroblasts are an easily accessible source of primary cells. Here, we discuss a simple and quick experimental procedure to establ...
متن کاملA Light and Electron Microscope Study of Long-term Organized Cultures of Rat Dorsal Root Ganglia
Dorsal root ganglia from fetal rats were explanted on collagen-coated coverslips and carried in Maximow double-coverslip assemblies for periods up to 3 months. These cultured ganglia were studied in the living state, in stained whole mounts, and in sections after OsO(4) fixation and Epon embedment. From the central cluster of nerve cell bodies, neurites emerge to form a rich network of fascicle...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1922
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.36.4.393