CTLA4 polymorphism and primary Sjögren's syndrome

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CTLA4 polymorphism and primary Sjögren's syndrome

The March 2007 issue of Arthritis Research and Therapy included a research article by Gottenberg and colleagues [1] that reports a failure to confirm our previous study [2] of a genetic association between CTLA4 and primary Sjögren's syndrome (pSS). Similar to our study, the Gottenberg study analysed both CTLA4 CT60 and +49A/G single nucleotide polymorphisms (SNPs). They observed an association...

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CTLA-4 polymorphism and primary Sjögren's syndrome: authors' response

We thank Dr Lester and colleagues [1] for their interest in our recent article [2] and for their comments. As underlined by Lester and colleagues [1], replication cohorts are of primary importance in genetic association studies. With regard to primary Sjögren's syndrome (pSS), however, it is difficult to collect a very large group of patients and our cohort of pSS patients, even though it compr...

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Association of Sjögrens Syndrome in Patients with Chronic Hepatitis Virus Infection: A Population-Based Analysis

OBJECTIVE The association between Sjögren's syndrome (SS) and chronic hepatitis virus infection is inconclusive. Hepatitis B (HBV) and hepatitis C virus (HCV) infections are highly prevalent in Taiwan. We used a population-based case-control study to evaluate the associations between SS and HBV and HCV infections. MATERIALS AND METHODS We identified 9,629 SS patients without other concomitant...

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CTLA4 polymorphisms and COPD.

We read with interest the article by ZHU et al. [1] describing the association of two single nucleotide polymorphisms (SNPs; rs231775 and rs3087243) within the CTLA4 gene and chronic bronchitis. Both of these polymorphisms may be risk factors for autoimmunity [2], and are often referred to as A49G and CT60, respectively. As alluded to briefly by the authors in their discussion, there has been r...

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An association between the CTLA4 exon 1 polymorphism and early rheumatoid arthritis with autoimmune endocrinopathies.

OBJECTIVE To examine the allelic association of the single nucleotide polymorphism (CTLA4A/G) in exon 1 of the cytotoxic T lymphocyte antigen-4 (CTLA4) gene with early rheumatoid arthritis (RA). METHODS One hundred and twenty-three unrelated white probands with early RA from the north-east of England and 349 local ethnically matched controls were studied. The CTLA4A/G polymorphism was genotyp...

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ژورنال

عنوان ژورنال: Arthritis Research & Therapy

سال: 2007

ISSN: 1478-6354

DOI: 10.1186/ar2196