CSI–FID: High throughput label-free detection of DNA binding molecules

Label-free, high-throughput, electrical detection of cells in droplets.

Today, droplet based microfluidics has become a standard platform for high-throughput single cell experimentation and analysis. However, until now no label-free, integrated single cell detection and discrimination method in droplets is available. We present here a microfluidic chip for fast (>100 Hz) and label-free electrical impedance based detection of cells in droplets. The microfluidic glas...

High-throughput label-free detection of DNA hybridization and mismatch discrimination using interferometric reflectance imaging sensor.

Optical label-free biosensors have demonstrated advantages over fluorescent-based detection methods by allowing accurate quantification while also being capable of measuring dynamic bimolecular interactions. A simple, high-throughput, solid-phase, and label-free technique, interferometric reflectance imaging sensor (IRIS), can quantify the mass density of DNA with pg/mm(2) sensitivity by measur...

Label-Free Detection of DNA

heterogeneous and dynamic problems of engineering technology and systems for industry and government. ISR is a permanent institute of the University of Maryland, within the Glenn L. Martin Institute of Technology/A. James Clark School of Engineering. It is a National Science Foundation Engineering Research Center. Web site http://www.isr.umd.edu I R INSTITUTE FOR SYSTEMS RESEARCH UNDERGRADUATE ...

High Resolution Electronics for Label Free Capacitive DNA Detection

Designing a Label Free Aptasensor for Detection of Methamphetamine

A label-free electrochemical nucleic acid aptasensor for the detection of methamphetamine (MA) by the immobilization of thiolated self-assembled DNA sequences on a gold nanoparticles-chitosan modified electrode is constructed. When MA was complexed specifically to the aptamer, the configuration of the nucleic acid aptamer switched to a locked structure and the interface of the biosensor changed...