CSF cytokine profile distinguishes multifocal motor neuropathy from progressive muscular atrophy

CSF cytokine profile distinguishes multifocal motor neuropathy from progressive muscular atrophy

OBJECTIVE We aimed to compare the cytokine and chemokine profiles of patients with multifocal motor neuropathy (MMN) with those of patients with progressive muscular atrophy (PMA) and amyotrophic lateral sclerosis (ALS) to investigate immunologic differences in the CNS. METHODS CSF from 12 patients with MMN, 8 with PMA, 26 with sporadic ALS, and 10 with other noninflammatory neurologic disord...

Cytokine profiles in multifocal motor neuropathy and progressive muscular atrophy

Multifocal motor neuropathy (MMN) and progressive muscular atrophy (PMA) are associated with IgM monoclonal gammopathy or the presence IgM anti-GM1-antibodies. To further investigate the pathophysiology of MMN and PMA we determined concentrations of 16 mainly B-cell associated inflammatory markers in serum from 25 patients with MMN, 55 patients with PMA, 25 patients with amyotrophic lateral scl...

Progressive Muscular Atrophy

a crack-like ulceration at the junction of the skin and mucous membrane in the two sides of the nose alternately?recurrent attacks of these two complainta during JDecember-January last in a case of progressive muscular atrophy was treated and cured with Bi, plunocaine and sulfanilamide mixed with honey. Was it correct to think that these troubles were of a trophic origin ? As to the P.M.A. the ...

Progressive Muscular Atrophy

Multifocal motor neuropathy.

We report the case of a patient with multifocal motor neuropathy. Electrophysiological studies showed typical multifocal conduction blocks, but the search for anti-GM1 antibodies was negative. This case provide the heterogeneity of this clinical entity.