CSF chitinase 3-like-1 association with disability of primary progressive MS
نویسندگان
چکیده
منابع مشابه
P 70: Primary Progressive MS and Affecting Genes
Multiple sclerosis is a CNS autoimmune disease configured by demyelination, inflammation, and degeneration of axons. This disease inflict great harms to patients. The most common problem is inability to control musculoskeletal system and decrease in mobility. These consequences could vary from patients to patients. About 10-15% of all MS patients develop primary progressive MS (PPMS). Despite t...
متن کاملNegative association between chitinase 3-Like-1 C-131G polymorphism and asthma-from a meta-analysis
The CHI3L1 gene has been widely regarded as a genetic candidate for asthma. Since the identification of functional polymorphism, CHI3L1 gene -131C/G (rs4950928), numbers of studies have been performed to estimate the relationship between it and asthma, but the results remain inconclusive. The present meta-analysis was conducted to evaluate the real association of CHI3L1 C-131G polymorphism on r...
متن کاملMale Sex Is Independently Associated with Faster Disability Accumulation in Relapse-Onset MS but Not in Primary Progressive MS
BACKGROUND Multiple Sclerosis is more common in women than men and females have more relapses than men. In a large international cohort we have evaluated the effect of gender on disability accumulation and disease progression to determine if male MS patients have a worse clinical outcome than females. METHODS Using the MSBase Registry, data from 15,826 MS patients from 25 countries was analys...
متن کاملChitinase 3-like 1: prognostic biomarker in clinically isolated syndromes.
Chitinase 3-like 1 (CHI3L1) has been proposed as a biomarker associated with the conversion to clinically definite multiple sclerosis in patients with clinically isolated syndromes, based on the finding of increased cerebrospinal fluid CHI3L1 levels in clinically isolated syndrome patients who later converted to multiple sclerosis compared to those who remained as clinically isolated syndrome. ...
متن کاملReduced rich-club connectivity is related to disability in primary progressive MS
OBJECTIVE To investigate whether the structural connectivity of the brain's rich-club organization is altered in patients with primary progressive MS and whether such changes to this fundamental network feature are associated with disability measures. METHODS We recruited 37 patients with primary progressive MS and 21 healthy controls for an observational cohort study. Structural connectomes ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Neurology - Neuroimmunology Neuroinflammation
سال: 2020
ISSN: 2332-7812
DOI: 10.1212/nxi.0000000000000815