CSE1L, DIDO1 and RBM39 in colorectal adenoma to carcinoma progression
نویسندگان
چکیده
منابع مشابه
Over-expression of AURKA, SKA3 and DSN1 contributes to colorectal adenoma to carcinoma progression
Development of colorectal cancer (CRC) involves sequential transformation of normal mucosal tissues into benign adenomas and then adenomas into malignant tumors. The identification of genes crucial for malignant transformation in colorectal adenomas (CRAs) has been based primarily on cross-sectional observations. In this study, we identified relevant genes using autologous samples. By performin...
متن کاملLumican and versican protein expression are associated with colorectal adenoma-to-carcinoma progression
BACKGROUND One prominent event associated with colorectal adenoma-to-carcinoma progression is genomic instability. Approximately 85% of colorectal cancer cases exhibit chromosomal instability characterized by accumulation of chromosome copy number aberrations (CNAs). Adenomas with gain of chromosome 8q, 13q, and/or 20q are at high risk of progression to cancer. Tumor progression is also associa...
متن کاملMultiple putative oncogenes at the chromosome 20q amplicon contribute to colorectal adenoma to carcinoma progression.
OBJECTIVE This study aimed to identify the oncogenes at 20q involved in colorectal adenoma to carcinoma progression by measuring the effect of 20q gain on mRNA expression of genes in this amplicon. METHODS Segmentation of DNA copy number changes on 20q was performed by array CGH (comparative genomic hybridisation) in 34 non-progressed colorectal adenomas, 41 progressed adenomas (ie, adenomas ...
متن کاملOncogenic Role of miR-15a-3p in 13q Amplicon-Driven Colorectal Adenoma-to-Carcinoma Progression
Progression from colorectal adenoma to carcinoma is strongly associated with an accumulation of genomic alterations, including gain of chromosome 13. This gain affects the whole q arm and is present in 40%-60% of all colorectal cancers (CRCs). Several genes located at this amplicon are known to be overexpressed in carcinomas due to copy number dosage. A subset of these genes, including the mir-...
متن کاملColorectal adenoma to carcinoma progression follows multiple pathways of chromosomal instability.
BACKGROUND & AIMS Current models of colorectal adenoma to carcinoma progression do not fully reflect the genetic heterogeneity and complexity of the disease. The aim of the present study was to identify genetic changes discriminating adenomas that have progressed to carcinoma from adenomas that have not progressed, and to refine the current genetic models of colorectal adenoma to carcinoma prog...
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ژورنال
عنوان ژورنال: Cellular Oncology
سال: 2012
ISSN: 2211-3428,2211-3436
DOI: 10.1007/s13402-012-0088-2