Cryptococcus laurentii meningitis in a non-HIV patient

Cryptococcus laurentii Diarrhea in a Neoplastic Patient

We present a rare case of diarrhea and neutropenia caused by Cryptococcus laurentii (C. laurentii) infection in old patient with metastatic rectal cancer who underwent FOLFOX plus Cetuximab chemotherapy. C. laurentii is an extremely rare human pathogen. To the best of our knowledge, here, we report the first case of diarrhea and neutropenia caused by C. laurentii in a 74-year-old man with metas...

Cryptococcus laurentii fungaemia in a cervical cancer patient.

Infections caused by emerging Cryptococcus non-neoformans species are being reported with increasingly frequency. Here, we present a case of fungaemia by Cryptococcus laurentii in a woman receiving aggressive immunosuppressive therapy for cervical neoplasia. Three venous blood samples were aseptically collected on consecutive days and C. laurentii was isolated and identified through phenotypic ...

Xylosyltransferases in Cryptococcus laurentii.

Heteroglycan synthesis in Cryptococcus laurentii.

An enzyme preparation from Cryptococcus laurentii catalyzes the transfer of glycosyl units from sugar nucleotides to exogenous acceptor resulting in the stepwise synthesis of a heteroglycan with the following structure: Z-O-a-n-mannosyl6-O-oc-D-mannosyl-3-~-~-D-mannosyl-(2 -0 -0 -D -xylosyl-) D-mannose. The same enzyme preparation transfers D-[‘T]mannosyl from GDP [WJmannose to an endogenous gl...

Mannosyl transfer in Cryptococcus laurentii.

A particle-bound enzyme from the fungus imperfectus Cryfitococcus taurentii var. flavescens (NRRL Y-1401) mediates transfer of mannosyl units from GDP-mannose to endogenous primer. The enzyme requires divalent cations for activity. The pH optimum is ‘7.5 and the apparent K, for GDP-mannose is 0.14 mbr. A polysaccharide fraction that is associated with the enzyme was found to be similar to a pol...