Cryoprobe-induced apical lesions in the chinchilla. I. Morphological effects of lesioning parameters

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چکیده

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Cryoprobe-induced apical lesions in the chinchilla. I. Morphological effects of lesioning parameters.

To create experimental lesions localized to the low frequency region of the organ of Corti, a cryoprobe was applied to the apical area of 37 cochleas from 26 adult chinchillas. Twenty cochleas were exposed to single applications of a cryoprobe for 2.5, 3.0 and 3.5 min; 17 cochleas were exposed to two applications of 1.5, 2.0 and 3.0 min each with about a 3 min interval between applications. Cry...

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Cryoprobe-induced apical lesions in the chinchilla. II. Effects on behavioral auditory thresholds.

Lesions of the hair cells in the cochlear apex were produced by a miniature cryoprobe and changes in behavioral auditory thresholds were measured. Monauralized adult chinchillas were behaviorally trained using operant procedures to produce pure-tone audiograms at frequencies from 63 Hz to 40 kHz. Following collection of baseline thresholds, the apical and middle turns of the experimental ear we...

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ژورنال

عنوان ژورنال: Hearing Research

سال: 1987

ISSN: 0378-5955

DOI: 10.1016/0378-5955(87)90065-7