Cryo-Electron Tomography of Homophilic Adhesion Mediated by the Neural Cell Adhesion Molecule L1
نویسندگان
چکیده
منابع مشابه
Cryo-electron tomography of homophilic adhesion mediated by the neural cell adhesion molecule L1.
The neural cell adhesion molecule L1 participates in homophilic interactions important for axon guidance and neuronal development. The structural details of homophilic adhesion mediated by L1 and other immunoglobulin superfamily members containing an N-terminal horseshoe arrangement of four immunoglobulin-like domains are unknown. Here we used cryo-electron tomography to study liposomes to whic...
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Mutations in the gene for neural cell adhesion molecule L1 (L1CAM) result in a debilitating X-linked congenital disorder of brain development. At the neuronal cell surface L1 may interact with a variety of different molecules including itself and two other CAMs of the immunoglobulin superfamily, axonin-1 and F11. However, whether all of these interactions are relevant to normal or abnormal deve...
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PECAM-1/CD31 is vascular cell adhesion and signaling molecule of the Ig superfamily that plays a role in neutrophil recruitment at inflammatory sites and may be involved the release of leukocytes from the bone marrow and in cardiovascular development. The interactions of PECAM-1 with its ligands are complex in that it is able to bind both with itself (homophilic adhesion) or with non-PECAM-1 li...
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http://bloodjournal.hematologylibrary.org/content/92/12/4602.full.html Updated information and services can be found at: (3094 articles) Hematopoiesis and Stem Cells Articles on similar topics can be found in the following Blood collections http://bloodjournal.hematologylibrary.org/site/misc/rights.xhtml#repub_requests Information about reproducing this article in parts or in its entirety ma...
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ژورنال
عنوان ژورنال: Structure
سال: 2009
ISSN: 0969-2126
DOI: 10.1016/j.str.2009.01.009