Cruzipain Promotes Trypanosoma cruzi Adhesion to Rhodnius prolixus Midgut
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Cruzipain Promotes Trypanosoma cruzi Adhesion to Rhodnius prolixus Midgut
BACKGROUND Trypanosoma cruzi is the etiological agent of Chagas' disease. Cysteine peptidases are relevant to several aspects of the T. cruzi life cycle and are implicated in parasite-mammalian host relationships. However, little is known about the factors that contribute to the parasite-insect host interaction. METHODOLOGY/PRINCIPAL FINDINGS Here, we have investigated whether cruzipain could...
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BACKGROUND Trypanosoma cruzi is the etiological agent of Chagas' disease. During the parasite life cycle, many molecules are involved in the differentiation process and infectivity. Peptidases are relevant for crucial steps of T. cruzi life cycle; as such, it is conceivable that they may participate in the metacyclogenesis and interaction with the invertebrate host. METHODOLOGY/PRINCIPAL FIND...
متن کاملB-u-1 – Trypanosoma Cruzi Incorporates Phospholipids from Rhodnius Prolixus’ Midgut
In insects the importance of lipid metabolism has been widely recognized. Neutral lipids and fatty acids constitute the major lipids of insect hemolymph whereas phospholipids are the main lipid class found in the midgut. In insect hemolymph lipophorins are the molecules responsible for lipid transfer between the tissues involved in lipid absorption, storage and utilization. We have previously d...
متن کاملMetalloproteases in Trypanosoma rangeli-infected Rhodnius prolixus.
Protease activities in the haemolymph and fat body in a bloodsucking insect, Rhodnius prolixus, infected with Trypanosoma rangeli, were investigated. After SDS-polyacrylamide gel electrophoresis containing gelatin as substrate, analysis of zymograms performed on samples of different tissues of controls and insects inoculated or orally infected with short or long epimastigotes of T. rangeli, dem...
متن کاملBehavioral fever response in Rhodnius prolixus (Reduviidae: Triatominae) to intracoelomic inoculation of Trypanosoma cruzi.
INTRODUCTION Behavioral fever is a response to infections with microorganisms observed in some poikilothermic animals. Rhodnius prolixus is involved in the transmission of two parasites: Trypanosoma cruzi (pathogenic for humans and transmitted in feces) and Trypanosoma rangeli (non-pathogenic for humans, pathogenic for Rhodnius and transmitted by the bite of an infected individual). Only T. ran...
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ژورنال
عنوان ژورنال: PLoS Neglected Tropical Diseases
سال: 2012
ISSN: 1935-2735
DOI: 10.1371/journal.pntd.0001958