منابع مشابه
Crumbs stands united against ROS
Lipins cause a lamina breakdown M all et al. reveal how lipid-making enzymes spur the demolition of the nuclear lamina in mitotic cells. Before a cell divides, it takes apart the lamina, the protein backing for the nuclear envelope. Cells remove the individual lamin proteins from the structure and save them for later reuse. At least two lamin-phosphorylating kinases, protein kinase C (PKC) and ...
متن کاملCrumbs turns the corner
rumbs (Crb) helps flies distinguish apical from basal in their epithelia. Now two new studies show that it is required for cell expansion independently of its specification of apical polarity. During cell expansion, the apical domain of photoreceptors elongates perpendicular to the apical–basal axis so that the domain can extend from the top to the bottom of the fly eye. The process may be cons...
متن کاملCyanine fluorophores for cellular protection against ROS in stimulated macrophages and two-photon ROS detection.
We report the first example of a novel two-photon active, biocompatible, and macrophage cell-membrane permeable carbazole-based cyanine fluorophore for the detection of three biologically important ROS, namely, ˙OH, O2(-) and OCl(-) in solution. This versatile probe shows cellular protection not only in stimulated macrophages from phorbol-12-myristate-13-acetate-induced morphological changes bu...
متن کاملDynein-mediated apical localization of crumbs transcripts is required for Crumbs activity in epithelial polarity
Asymmetrical localization of transcripts coupled with localized translation constitutes an important mechanism widely deployed to regulate gene activity in a spatial manner. The conserved transmembrane protein Crumbs (Crb) is an important regulator of epithelial polarity. However, it remains unclear how Crb is targeted to the apical domain. Here, we show that the cytoplasmic dynein complex tran...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2012
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.1986iti2