Cross-species oncogenomics using zebrafish models of cancer

Cross-Species Oncogenomics in Cancer Gene Identification

The complexity of genomic aberrations in most human tumors hampers delineation of the genes that drive the tumorigenic process. In this issue of Cell, and demonstrate that cognate mouse tumor models recapitulate these genetic alterations with unexpected fidelity. These results indicate that cross-species genomic analysis is a powerful strategy to identify the responsible genes and assess their ...

Novel candidate cancer genes identified by a large-scale cross-species comparative oncogenomics approach.

Comparative genomic hybridization (CGH) can reveal important disease genes but the large regions identified could sometimes contain hundreds of genes. Here we combine high-resolution CGH analysis of 598 human cancer cell lines with insertion sites isolated from 1,005 mouse tumors induced with the murine leukemia virus (MuLV). This cross-species oncogenomic analysis revealed candidate tumor supp...

In vivo immunotherapy of lung cancer using cross-species reactive vascular endothelial growth factor nanobodies

Objective(s): Lung cancer is the main leading cause of cancer death worldwide. Angiogenesis is the main step in proliferation and spreading of tumor cells. Targeting vascular endothelial growth factor (VEGF) is an effective approach for inhibition of cancer angiogenesis. Nanobodies (NBs) are a novel class of antibodies derived from the camel. Unique characteristics of Nbs like their small size ...

Zebrafish cancer models

Several models of cancer have been generated in zebrafish. Owing to space constraints, we will focus exclusively on heritable tumor models in the zebrafish. These are summarized in Tables 1 and 2. Table 1 lists all models according to cancer type and organ affected. The vast majority are transgenic lines expressing oncogenes driven by tissue-specific or ubiquitous promoters. Table 2 summarizes ...

A computational approach for comparative oncogenomics using mouse models