Cross-Sample Validation Provides Enhanced Proteome Coverage in Rat Vocal Fold Mucosa
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چکیده
منابع مشابه
Correction: Cross-Sample Validation Provides Enhanced Proteome Coverage in Rat Vocal Fold Mucosa
The vocal fold mucosa is a biomechanically unique tissue comprised of a densely cellular epithelium, superficial to an extracellular matrix (ECM)-rich lamina propria. Such ECM-rich tissues are challenging to analyze using proteomic assays, primarily due to extensive crosslinking and glycosylation of the majority of high M(r) ECM proteins. In this study, we implemented an LC-MS/MS-based strategy...
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OBJECTIVES Stellate cells in the maculae flavae, located at both ends of the human vocal fold mucosa, have been considered an independent category of cells. We aimed to isolate and subculture these stellate cells, and to observe their morphological characteristics. METHODS Stellate cells from the maculae flavae and fibroblasts from Reinke's space were cultured in three normal, adult human voc...
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Injuries of the vocal folds frequently heal with scar formation, which can have lifelong detrimental impact on voice quality. Current treatments to prevent or resolve scars of the vocal fold mucosa are highly unsatisfactory. In contrast, the adjacent oral mucosa is mostly resistant to scarring. These differences in healing tendency might relate to distinct properties of the fibroblasts populati...
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Voice is created as a consequence of vocal fold vibration. The quality of voice production is dependent upon the uniquely layered ultrastructure of the vocal folds, which is defined by its cellular and extracellular matrices (ECMs). Pathological changes of the vocal fold ECM alter vocal quality secondary to loss of normal vibratory function and alteration of tissue viscosity and thereby create ...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2011
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0017754