Cross-cancer pleiotropic analysis of endometrial cancer: PAGE and E2C2 consortia
نویسندگان
چکیده
منابع مشابه
Cross-cancer pleiotropic analysis of endometrial cancer: PAGE and E2C2 consortia.
Genome-wide association studies (GWAS) have identified a large number of cancer-associated single nucleotide polymorphisms (SNPs), several of which have been associated with multiple cancer sites suggesting pleiotropic effects and shared biological mechanisms across some cancers. We hypothesized that SNPs associated with other cancers may be additionally associated with endometrial cancer. We e...
متن کاملEndometrial cancer
کانسر آندومتر شایعترین بدخیمی دستگاه تناسلی زنان است، که تقریبا 7 درصد کانسرهای زنان را شامل می شود و چهارمین کانسر زنان بعد از کانسرهای (پستان، ریه و کلورکتال) در آمریکا است.
متن کاملPleiotropic effects of genetic risk variants for other cancers on colorectal cancer risk: PAGE, GECCO and CCFR consortia.
OBJECTIVE Genome-wide association studies have identified a large number of single nucleotide polymorphisms (SNPs) associated with a wide array of cancer sites. Several of these variants demonstrate associations with multiple cancers, suggesting pleiotropic effects and shared biological mechanisms across some cancers. We hypothesised that SNPs previously associated with other cancers may additi...
متن کاملPleiotropic Associations of Risk Variants Identified for Other Cancers With Lung Cancer Risk: The PAGE and TRICL Consortia
BACKGROUND Genome-wide association studies have identified hundreds of genetic variants associated with specific cancers. A few of these risk regions have been associated with more than one cancer site; however, a systematic evaluation of the associations between risk variants for other cancers and lung cancer risk has yet to be performed. METHODS We included 18023 patients with lung cancer a...
متن کاملHNF1B and Endometrial Cancer Risk: Results from the PAGE study
We examined the association between HNF1B variants identified in a recent genome-wide association study and endometrial cancer in two large case-control studies nested in prospective cohorts: the Multiethnic Cohort Study (MEC) and the Women's Health Initiative (WHI) as part of the Population Architecture using Genomics and Epidemiology (PAGE) study. A total of 1,357 incident cases of invasive e...
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ژورنال
عنوان ژورنال: Carcinogenesis
سال: 2014
ISSN: 0143-3334,1460-2180
DOI: 10.1093/carcin/bgu107