Cross-Bridge Cycling Kinetics Slow at Longer Muscle Length in Tetanic Contracting Mouse Soleus Muscle
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چکیده
منابع مشابه
Effect of muscle length on cross-bridge kinetics in intact cardiac trabeculae at body temperature
Dynamic force generation in cardiac muscle, which determines cardiac pumping activity, depends on both the number of sarcomeric cross-bridges and on their cycling kinetics. The Frank-Starling mechanism dictates that cardiac force development increases with increasing cardiac muscle length (corresponding to increased ventricular volume). It is, however, unclear to what extent this increase in ca...
متن کاملImpact of titin isoform on length dependent activation and cross-bridge cycling kinetics in rat skeletal muscle.
The magnitude of length dependent activation in striated muscle has been shown to vary with titin isoform. Recently, a rat that harbors a homozygous autosomal mutation (HM) causing preferential expression of a longer, giant titin isoform was discovered (Greaser et al. 2005). Here, we investigated the impact of titin isoform on myofilament force development and cross-bridge cycling kinetics as f...
متن کاملCharacterization of cross-bridge elasticity and kinetics of cross-bridge cycling during force development in single smooth muscle cells
Force development in smooth muscle, as in skeletal muscle, is believed to reflect recruitment of force-generating myosin cross-bridges. However, little is known about the events underlying cross-bridge recruitment as the muscle cell approaches peak isometric force and then enters a period of tension maintenance. In the present studies on single smooth muscle cells isolated from the toad (Bufo m...
متن کاملNitric oxide impairs Ca2+ activation and slows cross-bridge cycling kinetics in skeletal muscle.
The effects of the nitric oxide (NO) donor spermine NONOate (Sp-NO, 1.0 mM) on cross-bridge recruitment and cross-bridge cycling kinetics were studied in permeabilized rabbit psoas muscle fibers. Fibers were activated at various Ca2+ concentrations (pCa, negative logarithm of Ca2+ concentration), and the pCa at which force was maximal (pCa 4.0) and approximately 50% of maximal (pCa50 5.6) were ...
متن کاملNitric oxide impairs Ca activation and slows cross-bridge cycling kinetics in skeletal muscle
Heunks, Leo M. A., Mark J. Cody, Paige C. Geiger, P. N. Richard Dekhuijzen, and Gary C. Sieck. Nitric oxide impairs Ca21 activation and slows cross-bridge cycling kinetics in skeletal muscle. J Appl Physiol 91: 2233–2239, 2001.—The effects of the nitric oxide (NO) donor spermine NONOate (Sp-NO, 1.0 mM) on cross-bridge recruitment and cross-bridge cycling kinetics were studied in permeabilized r...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2020
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2019.11.1591