CRISPR clear? Dimeric Cas9-Fok1 nucleases improve genome-editing specificity
نویسندگان
چکیده
منابع مشابه
CRISPR clear? Dimeric Cas9-Fok1 nucleases improve genome-editing specificity.
tp://dx.doi.org/10.1016/j.gendis.2 52-3042/Copyright a 2014, Chongq Bacteria and archaea have been known for decades having evolvedadaptive immunedefenses calledclustered regularly interspaced short palindromic repeats (CRISPR)/CRISPRassociated (Cas) systems to degrade foreign nucleic acids. Recently, these RNA-guided Cas9 nucleases derived from CRISPR/Cas systems have shown promise in transfor...
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There are 9 Let7 family members present in keratinocytes, all acting as translational suppressors of the same target mRNAs. This redundancy implies that Let7 is crucial to cellular functioning, and it has indeed been found to act as a tumor suppressor, down regulating functions such as proliferation, cell motility, and de-differentiation. I hypothesized that increasing loss of Let7 loci would l...
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ژورنال
عنوان ژورنال: Genes & Diseases
سال: 2014
ISSN: 2352-3042
DOI: 10.1016/j.gendis.2014.08.004