CRISPR-Cas-Mediated Phage Resistance Enhances Horizontal Gene Transfer by Transduction

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CRISPR-Cas-Mediated Phage Resistance Enhances Horizontal Gene Transfer by Transduction

A powerful contributor to prokaryotic evolution is horizontal gene transfer (HGT) through transformation, conjugation, and transduction, which can be advantageous, neutral, or detrimental to fitness. Bacteria and archaea control HGT and phage infection through CRISPR-Cas (clustered regularly interspaced short palindromic repeats-CRISPR-associated proteins) adaptive immunity. Although the benefi...

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ژورنال

عنوان ژورنال: mBio

سال: 2018

ISSN: 2161-2129,2150-7511

DOI: 10.1128/mbio.02406-17