CREB regulation of BK channel gene expression underlies rapid drug tolerance
نویسندگان
چکیده
منابع مشابه
CREB regulation of BK channel gene expression underlies rapid drug tolerance.
Pharmacodynamic tolerance is believed to involve homeostatic mechanisms initiated to restore normal neural function. Drosophila exposed to a sedating dose of an organic solvent, such as benzyl alcohol or ethanol, acquire tolerance to subsequent sedation by that solvent. The slo gene encodes BK-type Ca(2+)-activated K(+) channels and has been linked to alcohol- and organic solvent-induced behavi...
متن کاملslo K(+) channel gene regulation mediates rapid drug tolerance.
Changes in neural activity caused by exposure to drugs may trigger homeostatic mechanisms that attempt to restore normal neural excitability. In Drosophila, a single sedation with the anesthetic benzyl alcohol changes the expression of the slo K(+) channel gene and induces rapid drug tolerance. We demonstrate linkage between these two phenomena by using a mutation and a transgene. A mutation th...
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Tolerance represents a critical component of addiction. The large-conductance calcium- and voltage-activated potassium channel (BK) is a well-established alcohol target, and an important element in behavioral and molecular alcohol tolerance. We tested whether microRNA, a newly discovered class of gene expression regulators, plays a role in the development of tolerance. We show that in adult mam...
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ژورنال
عنوان ژورنال: Genes, Brain and Behavior
سال: 2009
ISSN: 1601-1848,1601-183X
DOI: 10.1111/j.1601-183x.2009.00479.x