Creative interior design by Plasmodium falciparum: Lipid metabolism and the parasite's secret chamber

Malaria parasites conceal themselves within host erythrocytes and establish a necessary logistics system through the three-membrane layered structures of these cells. To this system, lipid metabolism is needed for de novo synthesis lipids recycling extracellular erythrocyte components. Cholesterol supply depends on its uptake from environment cytoplasm, but phospholipids can be synthesized their own. This differential production species creates unique modifications in profile parasitized erythrocytes, which turn may influence biophysical and/or mechanical properties organelles vesicles communication among them. Variations local membrane possibly transportation various molecules such as parasite-derived proteins, because efficiencies secretion, vesicle fusion budding are partly determined by profiles. Comprehensive understanding parasite's biophysics membranes provides fundamental knowledge about pathogenic organisms could lead to new anti-malarials.