CpGmotifs: a tool to discover DNA motifs associated to CpG methylation events
نویسندگان
چکیده
منابع مشابه
CpG methylation as a tool to characterize cell-free Kaposi sarcoma herpesvirus DNA.
We studied the presence of Kaposi sarcoma herpesvirus sequences in cell-free DNA (cfDNA) isolated from the blood of patients with AIDS-related Kaposi sarcoma (KS) and primary effusion lymphoma (PEL). The use of paramagnetic beads linked to methyl-CpG binding domain protein allowed separation of virion and cell-derived DNA. Only virion DNA was detected in the blood of KS patients, whereas cell-d...
متن کاملDiscovering DNA motifs and genomic variants associated with DNA methylation
DNA methylation plays a crucial role in establishing tissue-specific gene expression. However, our incomplete understanding of the cis elements that regulate DNA methylation prevents us from interpreting the functional effects of non-coding variants. We present CpGenie (http://cpgenie.csail.mit.edu), a deep convolutional neural network that learns a regulatory sequence code of DNA methylation a...
متن کاملDNA containing CpG motifs induces angiogenesis.
New blood vessel formation in the cornea is an essential step in the pathogenesis of a blinding immunoinflammatory reaction caused by ocular infection with herpes simplex virus (HSV). By using a murine corneal micropocket assay, we found that HSV DNA (which contains a significant excess of potentially bioactive "CpG" motifs when compared with mammalian DNA) induces angiogenesis. Moreover, synth...
متن کاملA Genetic Algorithm to Discover Flexible Motifs with Support
Finding repeated patterns or motifs in a time series is an important unsupervised task that has still a number of open issues, starting by the definition of motif. In this paper, we revise the notion of motif support, characterizing it as the number of patterns or repetitions that define a motif. We then propose GENMOTIF, a genetic algorithm to discover motifs with support which, at the same ti...
متن کاملA Genetic Algorithm to Discover Flexible Motifs with Support
Finding repeated patterns or motifs in a time series is an important unsupervised task that has still a number of open issues, starting by the definition of motif. In this paper, we revise the notion of motif support, characterizing it as the number of patterns or repetitions that define a motif. We then propose GENMOTIF, a genetic algorithm to discover motifs with support which, at the same ti...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: BMC Bioinformatics
سال: 2021
ISSN: 1471-2105
DOI: 10.1186/s12859-021-04191-8