CpG oligonucleotide and α-d-mannose conjugate for efficient delivery into macrophages
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چکیده
منابع مشابه
A Polyethylenimine-Linoleic Acid Conjugate for Antisense Oligonucleotide Delivery
A novel antisense oligonucleotide (ASO) carrier, polyethylenimine conjugated to linoleic acid (PEI-LA), was synthesized and evaluated for delivery of LOR-2501 to tumor cells. LOR-2501 is an ASO targeting ribonucleotide reductase R1 subunit (RRM1). In this study, PEI-LA was synthesized by reacting PEI (Mw ~ 800) with linoleoyl chloride. Gel retardation assay showed complete complexation between ...
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ژورنال
عنوان ژورنال: Applied Biological Chemistry
سال: 2016
ISSN: 2468-0834,2468-0842
DOI: 10.1007/s13765-016-0223-2