Coxsackievirus B4 Can Infect Human Peripheral Blood-Derived Macrophages
نویسندگان
چکیده
منابع مشابه
Coxsackievirus B4 Can Infect Human Peripheral Blood-Derived Macrophages.
Beyond acute infections, group B coxsackieviruses (CVB) are also reported to play a role in the development of chronic diseases, like type 1 diabetes. The viral pathogenesis mainly relies on the interplay between the viruses and innate immune response in genetically-susceptible individuals. We investigated the interaction between CVB4 and macrophages considered as major players in immune respon...
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Persistent replication of coxsackievirus B4 (CVB4) E2 (diabetogenic) and CVB4 JBV (nondiabetogenic) strains in thymic epithelial cell (TEC)-enriched cultures (>or=95%) was proved by detection of positive- and negative-strand viral RNA by reverse transcription-PCR in extracted RNA from cell cultures, VP1 capsid protein detection by immunofluorescence (IF) staining, and release of infectious part...
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ژورنال
عنوان ژورنال: Viruses
سال: 2015
ISSN: 1999-4915
DOI: 10.3390/v7112924