Covid-19: Government rolls out twice weekly rapid testing to all in England

Impaired expression of α-defensin antimicrobial peptides and overproduction the proinflammatory cytokine IL-1β have been associated with inflammatory bowel disease. In this study, we examine interactions between α-defensins role defensin deficiency in pathogenesis It was found that matrix metalloproteinase-7-deficient (MMP-7−/−) mice, which produce procryptdins but not mature cryptdins (α-defensins) intestine, were more susceptible to dextran sulfate sodium-induced colitis. Furthermore, both baseline production intestine significantly up-regulated MMP-7−/− mice compared control C57BL/6 mice. To elucidate molecular mechanism for increased vivo, evaluated effect defensins on posttranslational processing release. α-defensins, including mouse Paneth cell cryptdin-3 cryptdin-4, human neutrophil HNP-1, HD-5, blocked release from LPS-activated monocytes, whereas TNF-α affected. Unlike β-defensins do any Thus, may play an important intestinal homeostasis by controlling IL-1β.