Covariate determinants of effective dosing regimens for time-dependent beta-lactam antibiotics for critically ill patients
نویسندگان
چکیده
منابع مشابه
Beta-lactam antibiotics in continuous infusion in critically ill patients
article [1], published in a recent issue of Critical Care, on the insuffi cient β-lactam concentrations in the early phase of severe sepsis and septic shock. While we fully agree with the authors’ fi ndings, we would like to off er some remarks. Only 18 of their 80 patients (22.5%) were infected with Pseudomonas aeruginosa, but Taccone and colleagues used the European Committee on Antimicrobial...
متن کاملBeta-lactam dosing in critically ill patients with septic shock and continuous renal replacement therapy
Although early and appropriate antibiotic therapy remains the most important intervention for successful treatment of septic shock, data guiding optimization of beta-lactam prescription in critically ill patients prescribed with continuous renal replacement therapy (CRRT) are still limited. Being small hydrophilic molecules, beta-lactams are likely to be cleared by CRRT to a significant extent....
متن کاملOptimizing dosing of antibiotics in critically ill patients.
PURPOSE OF REVIEW Recent studies suggest that contemporary antibiotic dosing is unlikely to achieve best outcomes for critically ill patients because of extensive pharmacokinetic variability and altered pharmacodynamics. Dose adaptation is considered quite challenging because of unpredictable dose-exposure relationships. Consequently, individualization of antibiotic dosing has been advocated. H...
متن کاملContinuous infusion vs. bolus dosing: implications for beta-lactam antibiotics.
Beta-lactam antibiotics display time-dependant pharmacodynamics whereby constant antibiotic concentrations rather than high peak concentrations are most likely to result in effective treatment of infections caused by susceptible bacteria. Continuous administration has been suggested as an alternative strategy, to conventional intermittent dosing, to optimise beta-lactam pharmacokinetic/pharmaco...
متن کاملProtein Binding of Beta - Lactam Antibiotics in Critically Ill Patients : Can we successfully
Protein Binding of Beta-Lactam Antibiotics in Critically Ill Patients: Can we successfully 1 predict unbound concentrations? 2 3 Gloria Wong a , Scott Briscoe b , Syamhanin Adnan a , Brett McWhinney b , Jacobus Ungerer b , 4 Jeffrey Lipman a,c , Jason A. Roberts a,c# 5 6 a Burns Trauma and Critical Care Research Centre, The University of Queensland, Brisbane, 7 Queensland, Australia 8 b Chemica...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biomedical Papers
سال: 2018
ISSN: 1213-8118,1804-7521
DOI: 10.5507/bp.2018.011