Covalently bound pyrroloquinoline quinone is the organic prosthetic group in human placental lysyl oxidase
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منابع مشابه
Covalently bound flavin as prosthetic group of choline oxidase.
loxiazine ring. Effect of pH on fluorescence of the flavin peptide was shown in fig. 1. The fluorescence of the flavin peptide was quenched at neutral and alkaline pH ranges. This shows that the amino acid linked to flavin ring is a histidyl residue.6) The pKa. value of the flavin peptide was found to be about 4.6, which was almost identical with that of the authentic 8a-[7V(3)-histidyl]ribofla...
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Galactose oxidase from Dactylium dendroides was shown to contain one molecule of covalently bound pyrroloquinoline quinone (PQQ)/enzyme molecule. From the spectroscopic characteristics reported for the enzyme forms, a mechanistic role for PQQ could be deduced. In analogy with other quinoproteins, the initial formation of a PQQ-substrate adduct is proposed. Following internal hydrogen transfer, ...
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The observation that aliphatic diamines become poor substrates as the carbon chain length decreases and that ethylenediamine, the shortest diamine, is an irreversible inhibitor of lysyl oxidase led to the investigation of the mechanism of inhibition by ethylenediamine. The cis but not the trans isomer of 1,2-diaminocyclohexane was also a potent irreversible inhibitor of lysyl oxidase, consisten...
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This investigation was carried out at the Indian Institute of Science, Bangalore, where spectroscope facilities were available. The author is indebted to Sir J. C. Ghosh, Director, Indian Institute of Science, Bangalowe, for laboratory accommodation and to Mr M. Srinivasaya, Head of the Fermentation Technology Section at the Institute, for much helpful advice and discussion. Thanks are also due...
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L. (1995) Biochemistry 34, 11080-1 1089 10 Friden, H. and Hederstedt, L. (1990) Mol. Microbiol. 4, 1045-1056 1 1 Nakamura, K., Yamaki, M., Sarada, M., Nakayama, S., Vibat, C. R. T., Gennis, R. B., Nakayashiki, T., Inokuchi, H., Kojima, S. and Kita, K. (1996) J. Biol. Chem. 271, 521-527 12 Hagerhall, C. and Hederstedt, L. (1996) FEBS Lett. 389, 25-31 13 Pennoyer, J. D., Ohnishi, T. and Trumpower...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1986
ISSN: 0264-6021,1470-8728
DOI: 10.1042/bj2390789