Covalent Inhibition of the Lymphoid Tyrosine Phosphatase
نویسندگان
چکیده
منابع مشابه
The Mechanism of Allosteric Inhibition of Protein Tyrosine Phosphatase 1B
As the prototypical member of the PTP family, protein tyrosine phosphatase 1B (PTP1B) is an attractive target for therapeutic interventions in type 2 diabetes. The extremely conserved catalytic site of PTP1B renders the design of selective PTP1B inhibitors intractable. Although discovered allosteric inhibitors containing a benzofuran sulfonamide scaffold offer fascinating opportunities to overc...
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ژورنال
عنوان ژورنال: ChemMedChem
سال: 2014
ISSN: 1860-7179
DOI: 10.1002/cmdc.201300404