Counteracting age-related VEGF signaling insufficiency promotes healthy aging and extends life span

More VEGF, more life—and health span Advanced aging is celebrated but its ill effects, deterioration at the cell, tissue, and organ levels, are not. Grunewald et al . provide evidence for vascular theory of aging, which reports that age-related decrease function a driver organismal large (see Perspective by Augustin Kipnis). Vascular endothelial growth factor (VEGF) signaling insufficiency underlies this in aged mice. A modest compensatory increase circulatory VEGF was sufficient to preserve young-like homeostasis, alleviate multiple adverse processes, ameliorate host age-associated pathologies —BAP