COUNTER-CURRENT DISTRIBUTION STUDIES ON STREPTOMYCIN: THE TAUTOMERISM OF STREPTOMYCIN
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چکیده
منابع مشابه
Counter-current distribution studies on streptomycin; the tautomerism of streptomycin.
The simplicity and reproducibility which characterize the conversion of streptomycin to malt01 (1) by heating in dilute alkali have made this reaction the basis of a frequently used analytical method for streptomycin (2). When used in these laboratories as a method of assaying streptomycin preparations, however, the malt01 reaction consistently gave lower yields per unit of potency with pure st...
متن کاملSTUDIES ON STREPTOMYCIN VI. : The Effect of Streptomycin on the Metabolism of Multiplying Bacteria.
In a previous study the authors (Henry et al., 1948) reported on some of the effects of streptomycin (SM) on the metabolism of resting cells of Staphylococcus aureus, BaciUus cereus, and Shigella sonnei. It was found that SM inhibited the oxidation of certain carbohydrates and carbohydrate intermediates by susceptible strains of these organisms, but had no inhibitory effect on resistant strains...
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1; Heat extracts of mature mycelia of streptomycin-producing strains of Sfreptomyces contain two compounds which, when incubated with arginine-guanidino-‘*C plus a crude enzyme preparation from S. griseus ATCC 12475 containing a&nine: X amidinotrausferase, give products detected as radioactive Peaks I and II. Heat extracts from S. bluensis var. bluensis, which synthesizes bluensomycin, a monogu...
متن کاملStudies of the Streptomycin - Resistance System
NIQUE opportunities for the study of mutations, both spontaneous and U induced, have been offered by what we may call the " phage-resistance system '? of bacterial changes from sensitivity to resistance to bacteriophages. In studying this system it is easy to work with large numbers of bacteria (1 x 108 per Petri dish) ; and if sufficient quantities of phage are added, all sensitive bacteria wi...
متن کاملStreptomycin
ever, certain adjuvants, e.g. para-aminosalicylic acid, may delay the development of drug-resistance. Streptomycin is not absorbed from the alimentary tract and, therefore, it must always be given intramuscularly as well as directly, where possible, into the spaces which it is desired to render free from bacteria. The drug is excreted by the kidney. After intramuscular injection an adequate blo...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1948
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)57374-9