Coumarin Derivatives for Medicinal Purposes. XIII

The Antioxidant Activity of New Coumarin Derivatives

The antioxidant activity of two synthesized coumarins namely, N-(4,7-dioxo-2- phenyl-1,3-oxazepin-3(2H,4H,7H)-yl)-2-(2-oxo-2H-chromen-4-yloxy)acetamide 5 and N-(4-oxo-2-phenylthiazolidin-3-yl)-2-(2-oxo-2H-chromen-4-yloxy)acetamide 6 were studied with the DPPH, hydrogen peroxide and nitric oxide radical methods and compared with the known antioxidant ascorbic acid. Compounds 5 and 6 were synthes...

Optimization of the native glucagon sequence for medicinal purposes.

BACKGROUND Glucagon is a life-saving medication used in the treatment of hypoglycemia. It possesses poor solubility in aqueous buffers at or near physiological pH values. At low and high pH, at which the peptide can be formulated to concentrations of a milligram or more per milliliter, the chemical integrity of the hormone is limited, as evidenced by the formation of multiple degradation-relate...

Alcohol use of older adults: drinking alcohol for medicinal purposes

Inventory: comprehensive assessment of psychopathology in dementia. Neurology 1994; 44: 2308–14. 17. O’Bryant SE, Waring SC, Cullum CM et al. Staging dementia using clinical dementia rating scale sum of boxes scores. Arch Neurol 2008; 65: 1091–5. 18. Cigolle CT, Ofstedal MB, Tian Z et al. Comparing models of frailty: the Health and Retirement Study. JAGS 2009; 57: 830–839. 19. Radloff L. The CE...

Antibacterial activity of South African plants used for medicinal purposes.

Crude extracts from 21 South African medicinal plants, traditionally used for ailments of an infectious or septic nature, were screened for in vitro antibacterial activity using the agar diffusion and dilution methods. Almost all the activity exhibited was against Gram-positive bacteria, with 12 of the 21 plant species tested showing some activity against Bacillus subtilis. Only the Warburgia s...

Alcohol use of older adults: drinking alcohol for medicinal purposes.