Could Disappearance of Endemic (Balkan) Nephropathy Be Expected in Forthcoming Decades
نویسندگان
چکیده
منابع مشابه
Could Balkan Nephropathy be a Disorder of Renal Embryogenesis?
Introduction The etiology of Balkan endemic nephropathy (BEN) remains unknown despite numerous investigations carried out during the last 50 years. The pathophysiology of this disease remains unclear too, and there is no pathognomonic finding, which can confirm or discard the diagnosis of Balkan nephropathy in any particular patient. The widely accepted concept, however, is that Balkan nephropa...
متن کاملEndemic (Balkan) nephropathy is aristolochic acid nephropathy.
Endemic nephropathy is a syndrome that comprises two entities: chronic interstitial nephropathy and urothelial cell cancers predominantly of the upper urinary tract. The etiological agent for the disease is aristolochic acid, a compound found in the plants of Aristolochia spp. The development of urothelial cancers is characterized by the formation of aristolactam DNA adducts leading to mutation...
متن کاملEarly Screening of Balkan Endemic Nephropathy
Introduction Balkan endemic nephropathy (BEN) is a chronic irreversible interstitial sclerosis, for which over the last 25 years, chronic exposure to aristolochic acid from the contaminated cereal seeds has been considered the most likely cause. The aim of our research is to reevaluate trends of disease and to try to obtain new information about practical implementing of in-field screening of B...
متن کاملWeathered Coal Deposits and Balkan Endemic Nephropathy
The correlation between the geographic occurrence of Balkan endemic nephropathy (BEN) and low rank Pliocene lignites is striking. Comparison of mass spectra of methanol extracts from lignite samples collected in the vicinity of two endemic villages, with mass spectra of methanol extracts higher grade coals, shows the presence of many more potentially nephrotoxic compounds, and much higher total...
متن کاملBalkan Endemic Nephropathy: an Update Renal Interstitial Fibrosis Is a Major Feature of Balkan Endemic Nephropathy (ben)
RENAL INTERSTITIAL FIBROSIS IS A MAJOR FEATURE OF BALKAN ENDEMIC NEPHROPATHY (BEN) G. A. Müller, M. Zeisberg, F Strutz Dept. of Nephrology & Rheumatology, Georg-August Universität Göttingen, 37075 Göttingen, Germany Balkan Nephropathy is a common renal disease in the Balkan region which often leads to endstage renal failure. The pathogenesis of this disease is still unknown, however, the pathwa...
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ژورنال
عنوان ژورنال: Kidney and Blood Pressure Research
سال: 2012
ISSN: 1423-0143,1420-4096
DOI: 10.1159/000333836