Costunolide: A novel anti-cancer sesquiterpene lactone

Anti-proliferative effect and apoptotic induction of sesquiterpene lactone parthenolide in a human breast cancer cell line

Parthenolide is a secondary metabolite, which naturally occurs in the feverfew plant and is responsible for its healing power. The potential of parthenolide in inhibition of cancer cell growth, alone or in combination with other anti-cancer therapeutics, have been studied in several laboratories. In this study, the effect of extracted parthenolide on the expression of seven pro-apoptotic genes,...

The Antiinflammatory Sesquiterpene Lactone

Novel Sesquiterpene Lactone and Sesquiterpene Lactone Glucoside from the Flowers of the Tunisian Pulicaria Laciniata (coss. Et Kral.) Thell

* corresponding author, e-mail : [email protected] Abstract: A sesquiterpene lactone 1 Lacinin and a sesquiterpene lactone glucoside 2 Laciniside, were isolated from the flowers of Pulicaria laciniata. Their structures were elucidated by extensive spectroscopic methods including 1D-( 1 H and 13 C) and 2D-NMR experiments, (CHcorr, HMBC, 1 H1 H COSY and NOESY) as well as high resolution E...

Aromaticine, a sesquiterpene lactone from Amblyopappus pusillus

AROMATICINE (SYSTEMATIC NAME: 4a,8-dimethyl-3-methyl-ene-3,3a,4,4a,7a,8,9,9a-octa-hydro-azuleno[6,5-b]furan-2,5-dione), C(15)H(18)O(3), is a natural lactone isolated from Amblyopappus pusillus. The mol-ecular structure and conformation agree with the results of Romo, Joseph-Nathan & Díaz [(1964 ▶). Tetra-hedron, 20, 79-85]. The fused-ring system contains a seven-membered ring in a twist-boat co...

Cynaratriol, a sesquiterpene lactone from Centaurea musimomum

THE TITLE COMPOUND [SYSTEMATIC NAME: 3,8-dihydr-oxy-3-(hydroxy-meth-yl)-9-methyl-6-methyl-enedeca-hydro-azuleno[4,5-b]furan-2(3H)-one], C(15)H(22)O(5), is a sesquiterpene lactone showing the typical tricyclic guaianolide skeleton which has been isolated, together with other related metabolites, from the plant Centaurea musimomum. The present study confirms the mol-ecular structure, assigned by ...