Corynebacterium Cell Factory Design and Culture Process Optimization for Muconic Acid Biosynthesis
نویسندگان
چکیده
منابع مشابه
The optimization of Naringenin biosynthesis pathway using Yarrowia lipolitica cell culture
Yarrowia lipolytica, as a good cell factory to speed up the production of plant pharmaceutical components, has been considered to be one of the most important and attractive micro-organisms in recent years, due to its high secretion capacity, limited glycosylation, large range of genetic markers and molecular tools. Naringenin, as a central core of flavonoids production, plays important roles b...
متن کاملEvolutionary process of amino acid biosynthesis in Corynebacterium at the whole genome level.
Corynebacterium glutamicum, which is the closest relative of Corynebacterium efficiens, is widely used for the large scale production of many kinds of amino acids, particularly glutamic acid and lysine, by fermentation. Corynebacterium diphtheriae, which is well known as a human pathogen, is also closely related to these two species of Corynebacteria, but it lacks such productivity of amino aci...
متن کاملVirtual Factory as an Advanced Approach for Production Process Optimization
This paper demonstrates a new methodology for designing a virtual factory model and model execution on the basis of a real schedule plan. The main characteristic of the developed method is that the inputs are regarded as one of the main parameters of the production process, and the main objective is to create a low-cost production process model. The methodology is adjusted for use in SMEs (Smal...
متن کاملAutomated dynamic fed-batch process and media optimization for high productivity cell culture process development.
Current industry practices for large-scale mammalian cell cultures typically employ a standard platform fed-batch process with fixed volume bolus feeding. Although widely used, these processes are unable to respond to actual nutrient consumption demands from the culture, which can result in accumulation of by-products and depletion of certain nutrients. This work demonstrates the application of...
متن کاملCell Factory Design and Optimization for the Stereoselective Synthesis of Polyhydroxylated Compounds.
A synthetic cascade for the transformation of primary alcohols into polyhydroxylated compounds in Escherichia coli, through the in situ preparation of cytotoxic aldehyde intermediates and subsequent aldolase-mediated C-C bond formation, has been investigated. An enzymatic toolbox consisting of alcohol dehydrogenase AlkJ from Pseudomonas putida and the dihydroxyacetone-/hydroxyacetone-accepting ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Scientific Reports
سال: 2018
ISSN: 2045-2322
DOI: 10.1038/s41598-018-36320-4