Corticotropin releasing hormone receptor 2 exacerbates chronic cardiac dysfunction

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Corticotropin releasing hormone receptor 2 exacerbates chronic cardiac dysfunction

Heart failure occurs when the heart is unable to effectively pump blood and maintain tissue perfusion. Despite numerous therapeutic advancements over previous decades, the prognosis of patients with chronic heart failure remains poor, emphasizing the need to identify additional pathophysiological factors. Here, we show that corticotropin releasing hormone receptor 2 (Crhr2) is a G protein-coupl...

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Corticotropin-releasing hormone (CRH) is a key mediator of endocrine, autonomic, behavioral, and immune responses to stress. In response to stress, CRH released from the hypothalamic paraventricular nucleus (PVN) activates CRH receptor on the anterior pituitary corticotrophes, resulting in secretion of adrenocorticotropic hormone (ACTH) into the bloodstream. Two CRH receptors, CRH-receptor type...

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Corticotropin-releasing hormone (CRH), also known as corticotropin-releasing factor, is a highly conserved peptide hormone comprising 41 amino acid residues. Its name derives from its role in the anterior pituitary, where it mediates the release of corticotropin (ACTH) leading to the release of adrenocortical steroids. CRH is the major hypothalamic activator of the hypothalamic–pituitary– adren...

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ژورنال

عنوان ژورنال: Journal of Experimental Medicine

سال: 2017

ISSN: 0022-1007,1540-9538

DOI: 10.1084/jem.20161924