Cortical disinhibition in Parkinson’s disease

Evaluating cortical disinhibition signs.

Automatic, unsupervised classification of dyskinesia in patients with Parkinsons Disease

One of the characteristic symptoms of patients with Parkinson Disease (PD) is a rigidity of movement. These symptoms disappear after administration of Levodopa. However, the long-term use of levodopa causes involuntary movements (dyskinesia). A proper diagnosis requires an automatic, unsupervised method for the detection and classification of levodopa induced dyskinesia. The main problem, howev...

Investigation of Motor Cortical Plasticity and Corticospinal Tract Diffusion Tensor Imaging in Patients with Parkinsons Disease and Essential Tremor

Parkinson's disease (PD) and essential tremor (ET) are characterized with motor dysfunctions. Motor circuit dysfunctions can be complementarily investigated by paired associative stimulation (PAS)-induced long-term potentiation (LTP)-like plasticity and diffusion tensor imaging (DTI) of the corticospinal tract (CST). Three groups of twelve subjects with moderate severity PD, ET with intention t...

Neural Mechanisms of Short-term Visual Plasticity and Cortical Disinhibition

iii ACKNOWLEDGEMENTS I wish to thank my advisor, Paul Corballis, for his guidance, patience, and friendship all these years. Without his mentorship I could never have made it this far. I would also like to thank my dissertation committee members Parks have always been a major source of inspiration and support. I cannot thank them enough. Most of all, I must express an incredible degree gratitud...

Cognitive deficits caused by prefrontal cortical and hippocampal neural disinhibition.

We review recent evidence concerning the significance of inhibitory GABA transmission and of neural disinhibition, that is, deficient GABA transmission, within the prefrontal cortex and the hippocampus, for clinically relevant cognitive functions. Both regions support important cognitive functions, including attention and memory, and their dysfunction has been implicated in cognitive deficits c...