Correlation of Surrogate Markers of Insulin Resistance with Fasting Insulin in Type 2 Diabetes Mellitus Patients: A Study of Malwa Population in Punjab, India

Abstract Context Insulin resistance (IR) and abnormal insulin secretion play a key role for the development of type 2 diabetes mellitus (DM). Aims We investigated surrogate markers IR, i.e., Homeostasis Model Assessment (HOMA), Quantitative Sensitivity Check Index (QUICKI), McAuley, Fasting Resistance (FIRI) in DM patients. Also, fasting (FI) levels were estimated diabetics. Further, correlation FI with other IR was done. Settings Design A hundred newly diagnosed patients from Malwa population, Punjab, considered evaluation. Another 100 healthy individuals (age sex-matched) examined as controls. Methods Material blood glucose, FI, lipid profile estimated, calculated using McAuley index (McA), HOMA, QUICKI, FIRI. Statistical Analysis Used The statistical analysis performed on above-mentioned clinical interpretations. Cohen’s kappa test used to affirm agreement. Results significantly higher (20.8 ± 9.05 µIU/L) than controls (7.93 1.01 µIU/L). by found significant study group. 76% ended up resistant measurement, almost equivalent McA, 80%; 88%; FIRI, 90%. notable highlighted between McA manifesting (p < 0.01, r = −0.85). FIRI indices 0.93; p 0.01 −0.92; +0.93, respectively). agreement visible also affirms same (k 0.9 McA). Conclusion concluded that all specific when compared but terms sensitivity be more sensitive it includes dyslipidemia, which is precipitating factor metabolic derangements so DM.