Correlation of serum acute-phase proteins with bone repair in rabbits (Oryctolagus cuniculus) submitted to partial radio ostectomy

ABSTRACT: Bone trauma triggers an acute inflammatory response, which can alter the serum concentration of acute-phase proteins (PFA). We aimed to evaluate effectiveness PFA measurement as a laboratory biomarker for inflammation related bone regeneration. A partial ostectomy right radius was performed on 22 young male rabbits. The complete blood count, albumin, ceruloplasmin, haptoglobin, C-reactive protein, and transferrin levels were recorded correlated with radiographic evolution healing. Statistically best correlations process radiological findings reported haptoglobin compared other measured PFAs. Haptoglobin showed maximum peak 24 36 hours after surgery, respectively. Transferrin displayed signs decrease in first 6 advance leukocyte response. proved be viable, considering conditions present study carried out. Among all variables studied, correlation Additional studies are needed determine sensitivity predictors complications treatment fractures.