Correlation of Population Parameters Leading to Power Differences In Association Studies with Population Stratification
نویسندگان
چکیده
منابع مشابه
Correction of Population Stratification in Large Multi-Ethnic Association Studies
BACKGROUND The vast majority of genetic risk factors for complex diseases have, taken individually, a small effect on the end phenotype. Population-based association studies therefore need very large sample sizes to detect significant differences between affected and non-affected individuals. Including thousands of affected individuals in a study requires recruitment in numerous centers, possib...
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Population stratification and its influence on genetic association studies is a controversial topic. Although it has been suggested that stratification is unlikely to bias the results of association studies conducted in developed countries, convincing contrary empirical evidence has been published. However, it is in populations where historical ethnic, religious and language barriers exist that...
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ژورنال
عنوان ژورنال: Annals of Human Genetics
سال: 2008
ISSN: 0003-4800,1469-1809
DOI: 10.1111/j.1469-1809.2008.00465.x