Correlation between expression of hTERT and α -β splice variants in human brain tumors
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چکیده
منابع مشابه
Differential expression of α-synuclein splice variants in the brain of alcohol misusers: Influence of genotype.
BACKGROUND Chronic alcohol misuse causes damage in the central nervous system that may lead to tolerance, craving and dependence. These behavioural changes are likely the result of cellular adaptations that include changes in gene expression. α-Synuclein is involved in the dopaminergic reward pathway, where it regulates dopamine synthesis and release. Previous studies have found that the gene f...
متن کاملMDS shows a higher expression of hTERT and alternative splice variants in unactivated T-cells
Telomere instability and telomerase reactivation are believed to play an important role in the development of myelodysplastic syndromes (MDS). Abnormal enzymatic activity of human telomerase reverse transcriptase (hTERT), and its alternative splice variants have been reported to account for deregulated telomerase function in many cancers. In this study, we aim to compare the differences in expr...
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Estrogen receptor α (ERα) isoforms with complex types of alternative splicing are naturally present in the human brain and may affect canonical receptor signaling. In the present study we investigated transcriptional activity of common ERα splice variants from this group with different molecular defects: MB1 (intron retention), TADDI (small deletion between exons 3 and 4 with an insert), the Δ ...
متن کاملβ Subunits Functionally Differentiate Human Kv4.3 Potassium Channel Splice Variants
The human ventricular cardiomyocyte transient outward K+ current (Ito) mediates the initial phase of myocyte repolarization and its disruption is implicated in Brugada Syndrome and heart failure (HF). Human cardiac Ito is generated primarily by two Kv4.3 splice variants (Kv4.3L and Kv4.3S, diverging only by a C-terminal, S6-proximal, 19-residue stretch unique to Kv4.3L), which are differentiall...
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ژورنال
عنوان ژورنال: Advances in Clinical and Experimental Medicine
سال: 2019
ISSN: 1899-5276
DOI: 10.17219/acem/81934