Correction to: Automatic reconstruction of metabolic pathways from identified biosynthetic gene clusters
نویسندگان
چکیده
منابع مشابه
Chromatin-level regulation of biosynthetic gene clusters.
Loss-of-function Aspergillus nidulans CclA, a Bre2 ortholog involved in histone H3 lysine 4 methylation, activated the expression of cryptic secondary metabolite clusters in A. nidulans. One new cluster generated monodictyphenone, emodin and emodin derivatives, whereas a second encoded two anti-osteoporosis polyketides, F9775A and F9775B. Modification of the chromatin landscape in fungal second...
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Investigations during the last three decades have shown that ace c acid is one of the most important building units for the synthesis of complex organic molecules found in Nature. This insight is primarily due to the application of tracer techniques to biosynthetic problems. Despite all the admiration this method deserves, we should not forget, however, that organic chemists, full of imaginatio...
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Natural product scaffolds remain a major source and inspiration for human therapeutics. However, generation of a natural product in the post-genomic era often requires reconstruction of the corresponding biosynthetic gene cluster in a heterologous host. In the burgeoning fields of synthetic biology and metabolic engineering, a significant amount of efforts has been devoted to develop DNA assemb...
متن کاملReconstruction of phylogenetic relationships from metabolic pathways based on the enzyme hierarchy and the gene ontology.
There has been much interest in the structural comparison and alignment of metabolic pathways. Several techniques have been conceived to assess the similarity of metabolic pathways of different organisms. In this paper, we show that the combination of a new heuristic algorithm for the comparison of metabolic pathways together with any of three enzyme similarity measures (hierarchical, informati...
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BACKGROUND Fumaric acid is a commercially important component of foodstuffs, pharmaceuticals and industrial materials, yet the current methods of production are unsustainable and ecologically destructive. RESULTS In this study, the fumarate biosynthetic pathway involving reductive reactions of the tricarboxylic acid cycle was exogenously introduced in S. cerevisiae by a series of simple genet...
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ژورنال
عنوان ژورنال: BMC Bioinformatics
سال: 2021
ISSN: 1471-2105
DOI: 10.1186/s12859-021-04094-8