Copy number variation in the susceptibility to systemic lupus erythematosus
نویسندگان
چکیده
منابع مشابه
Neurobrucellosis in systemic lupus erythematosus
Background: Brucellosis is a zoonotic infection which is endemic in many countries. It is a multisystem disease which may present with a broad spectrum of clinical manifestations and complications. Neurobrucellosis is an uncommon complication of brucellosis. Case presentation: A 25-year-old woman with a history of lupus for 5 months referred to the emergency ward of Shahid Beheshti Hosp...
متن کاملCopy number variants in genetic susceptibility and severity of systemic lupus erythematosus.
Systemic lupus erythematosus (SLE) is a systemic autoimmune disorder characterized by the presence of auto-antibodies to nuclear antigens, immune complex deposition, and subsequent tissue destruction. Early studies in twins suggested that SLE has, at least in part, a genetic basis, and a role for class II alleles in the major histocompatibility complex has been known for over 30 years. Through ...
متن کاملFCGR3B copy number variation is associated with systemic lupus erythematosus risk in Afro-Caribbeans.
OBJECTIVES To evaluate FCGR3B copy number variation (CNV) in African and European populations and to determine if FCGR3B copy number is associated with SLE and SLE nephritis risk in Afro-Caribbeans, adjusting for African genetic ancestry. METHODS We estimated FCGR3B to determine if there were ethnic variations in CNV (unrelated unadmixed Europeans and Africans). We then examined CNV at FCGR3B...
متن کاملConcise report FCGR3B copy number variation is associated with systemic lupus erythematosus risk in Afro-Caribbeans
Objectives. To evaluate FCGR3B copy number variation (CNV) in African and European populations and to determine if FCGR3B copy number is associated with SLE and SLE nephritis risk in Afro-Caribbeans, adjusting for African genetic ancestry. Methods. We estimated FCGR3B to determine if there were ethnic variations in CNV (unrelated unadmixed Europeans and Africans). We then examined CNV at FCGR3B...
متن کاملassociation of hla-dqb1 allelic sequence variation with susceptibility to systemic lupus erythematosus
systemic lupus erythematosus (sle) is an autoimmune disease in which polymorphisms within the human leukocyte antigen (hla) region have been associated to its etiology. we conducted this study to compare the hla-dqb1 allelic sequence variation among sle patients and controls in the northeast of iran. genomic dna of 40 sle patients and 83 healthy controls were amplified by polymerase chain react...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2018
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0206683