Coordinate control of gene expression noise and interchromosomal interactions in a MAP kinase pathway

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Coordinate control of gene expression noise and interchromosomal interactions in a MAP kinase pathway

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Cis-regulatory control of transcription is the dominant form of regulation of gene expression. Recent experimental results suggest that, in addition to the mean expression level, cell-to-cell variability might also be transcriptionally regulated. Here, we develop a stochastic model of transcriptional regulation that allows us to calculate closed-form analytical expressions for the mean and vari...

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ژورنال

عنوان ژورنال: Nature Cell Biology

سال: 2010

ISSN: 1465-7392,1476-4679

DOI: 10.1038/ncb2097