Cooperativity and equilibrium with FOXA1 define the androgen receptor transcriptional program
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منابع مشابه
Cooperativity and Equilibrium with FOXA1 Define the Androgen Receptor Transcriptional Program
The pioneering factor FOXA1 opens chromatin to facilitate androgen receptor (AR) binding to prostate-specific genes. How FOXA1 controls the AR cistrome, however, is incompletely understood. Here we show that AR directly binds chromatin through the androgen response elements (AREs). FOXA1 is not required for AR-chromatin interaction, but instrumental in recruiting AR to low-affinity half-AREs by...
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As you will see from the enclosed reports, all three scientists appreciate your results. At the same time, refs #1and #3 recommend further experimentation to increase the significance of the study. Particularly, the presented time-points/DHT-dosages are issues that need to be addressed. Further, corroborating the AR-target gene categorization in prostate cancer models (ref#3 point 1) as well as...
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Androgens control a variety of developmental processes that create the male phenotype and are important for maintaining male fertility and normal functions of tissues and organs that are not directly involved in procreation. Androgen receptor (AR) that mediates the biological actions of androgens is a member of the nuclear receptor superfamily of ligand-inducible transcription factors. Although...
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ژورنال
عنوان ژورنال: Nature Communications
سال: 2014
ISSN: 2041-1723
DOI: 10.1038/ncomms4972