Convergence of Canonical and Non-Canonical Wnt Signal: Differential Kat3 Coactivator Usage
نویسندگان
چکیده
منابع مشابه
Differential expression of canonical and non-canonical Wnt ligands in ameloblastoma.
BACKGROUND Canonical and non-canonical Wnt signaling pathways modulate diverse cellular processes during embryogenesis and post-natally. Their deregulations have been implicated in cancer development and progression. Wnt signaling is essential for odontogenesis. The ameloblastoma is an odontogenic epithelial neoplasm of enamel organ origin. Altered expressions of Wnts-1, -2, -5a, and -10a are d...
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Precise regulation of signal transduction pathways is crucial for normal animal development and for maintaining cellular and tissue homeostasis in adults. The Wnt/Frizzled-mediated signaling includes canonical and non-canonical signal transduction pathways. Upregulation or downregulation of the canonical Wnt-signaling (or the Wnt/β-Catenin signal transduction) leads to a variety of human diseas...
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Wnt proteins control diverse biological processes through β-catenin-dependent canonical signalling and β-catenin-independent non-canonical signalling. The mechanisms by which these signalling pathways are differentially triggered and controlled are not fully understood. Dishevelled (Dvl) is a scaffold protein that serves as the branch point of these pathways. Here, we show that cholesterol sele...
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INTRODUCTION Canonical and non-canonical Wnt pathways are involved in the genesis of multiple tumors; however, their role in pituitary tumorigenesis is mostly unknown. OBJECTIVE This study evaluated gene and protein expression of Wnt pathways in pituitary tumors and whether these expression correlate to clinical outcome. MATERIALS AND METHODS Genes of the WNT canonical pathway: activating l...
متن کاملFunctional Consequences of Wnt-Induced Dishevelled2 Phosphorylation in Canonical and Non-Canonical Signaling*
Background: Wnt signaling causes phosphorylation of Dishevelled, but its functional significance is unclear. Result: Sites of Wnt-induced phosphorylation were mapped in Dvl2 and mutated to permit functional testing. Conclusion: Three CK1 phosphorylation sites in the C-terminal of Dvl2 account for the Wnt induced mobility shift and modulate signaling. Significance: Wnt-induced phosphorylation of...
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ژورنال
عنوان ژورنال: Current Molecular Pharmacology
سال: 2019
ISSN: 1874-4672
DOI: 10.2174/1874467212666190304121131