Conventional calpains and programmed cell death.
نویسندگان
چکیده
منابع مشابه
Conventional calpains and programmed cell death.
The evidence on the crucial role of a family of calcium-dependent cysteine proteases called calpains in programmed cell death is rich and still growing. However, understanding of the mechanisms of their functions in apoptosis is not full yet. Calpains have been implicated in both physiological and pathological cell death control, especially in various malignancies, but also in the immune system...
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Apoptosis is a highly organized physiologic mechanism of destroying injured and abnormal cells as well as maintaining homeostasis in the multicellular organism. Apoptosis is tightly controlled at the genetic level and dysregulation of the apoptosis machinery may contribute to a variety of diseases. Pharmacologic manipulation of this pathway is a novel therapeutic target.
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ژورنال
عنوان ژورنال: Acta Biochimica Polonica
سال: 2011
ISSN: 1734-154X,0001-527X
DOI: 10.18388/abp.2011_2238