CONTROLLING AQUACULTURE PATHOGEN BIOFILM BY CRUDE EXTRACT AND SUPERNATANT OF PHYLLOSPHERE BACTERIA

Some infectious-aquaculture pathogens, such as Aeromonas hydrophila, Vibrio harveyi, and Streptococcus agalactiae are able to form biofilm, a protective structure that increases bacterial resistance some external exposures, for example the antibiotic therapy, making becomes less effective. This ability is supported by quorum sensing mechanism. Therefore, disruption in mechanism may be potential way treat biofilm formation. The present study was conducted assess of supernatant crude extract Actinobacteria phyllosphere bacteria isolates overcome biofilms several aquaculture pathogens. In general, this consists steps, primary screening anti-quorum activity, extraction bioactive compounds, antibiofilm assay, validation toxicity microscopic observation biofilm. showed higher activity compared isolate, where had most instead supernatant. all also performed activities, both qualitatively quantitatively. Overall, were natural sources agents control pathogens used through disruption.