Control of Plasma Uric Acid in Adults at Risk for Tumor Lysis Syndrome: Efficacy and Safety of Rasburicase Alone and Rasburicase Followed by Allopurinol Compared With Allopurinol Alone—Results of a Multicenter Phase III Study
نویسندگان
چکیده
منابع مشابه
Effects of Recombinant Urate Oxidase (Rasburicase) and Allopurinol for Prophylaxis and Treatment of Hyperuricemia in Patients with Leukemia and Lymphoma
Background: Efficacy of rasburicase in pediatric patients with leukemia and lymphoma is proved. This study aims toweigh efficacy and safety of rasburicase versus more conventional therapy, allopurinol, and to compare their safetyand properties in tumor lysis syndrome (TLS) of leukemia and lymphoma patients.Materials and Methods: The study was done with a retrospective cohort design. Patients we...
متن کاملA randomized comparison between rasburicase and allopurinol in children with lymphoma or leukemia at high risk for tumor lysis.
Standard therapy in the United States for malignancy-associated hyperuricemia consists of hydration, alkalinization, and allopurinol. Urate oxidase catalyzes the enzymatic oxidation of uric acid to a 5 times increased urine soluble product, allantoin. Rasburicase is a new recombinant form of urate oxidase available for clinical evaluation. This multicenter randomized trial compared allopurinol ...
متن کاملThe Efficacy of Single Dose Rasburicase in Prevention or Treatment of Tumor Lysis Syndrome in Children
Background: Tumor lysis syndrome (TLS) is a major metabolic complication in patients with malignancy after initiation of chemotherapy or spontaneously without treatment. The role of Rasburicase (a recombinant urate-oxidase enzyme) in prevention and treatment of TLS has been demonstrated in recent years. We aimed to investigate the efficacy of a single dose of rasburicase in reducing the risk of...
متن کاملCLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS A randomized comparison between rasburicase and allopurinol in children with lymphoma or leukemia at high risk for tumor lysis
Standard therapy in the United States for malignancy-associated hyperuricemia consists of hydration, alkalinization, and allopurinol. Urate oxidase catalyzes the enzymatic oxidation of uric acid to a 5 times increased urine soluble product, allantoin. Rasburicase is a new recombinant form of urate oxidase available for clinical evaluation. This multicenter randomized trial compared allopurinol ...
متن کاملاثر راسبوریکیس وآلوپورینول در پیشگیری و درمان بیماران مبتلا به هیپراوریسمی ناشی از سندروم لیز تومور در کودکان مبتلا به لوسمی و لنفوم در بیمارستان کودکان حضرت علی اصغر(ع): مطالعه کوهورت
Background: Tumor Lysis Syndrome (TLS) is the release of intracellular material into blood stream by itself or due to anticancer cytolytic therapies. Hyperuricemia, hyperkalemia, hyperphosphatemia and hypocalcemia are the main metabolic disorders of TLS. In order to treat and prevent hyperuricemia in TLS, we used Allopurinol and a new drug- Rasburicase. The aim of this study was to compare ...
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ژورنال
عنوان ژورنال: Journal of Clinical Oncology
سال: 2010
ISSN: 0732-183X,1527-7755
DOI: 10.1200/jco.2009.26.8896