Control of Globin Gene Transcription
نویسندگان
چکیده
منابع مشابه
Tissue-specific transcription of the globin gene in isolated chromatin.
RNA was transcribed from chrmation from mouse fetal liver or brain, by use of DNA-dependent RNA polymerase of Escherichia coli. Globin messenger RNA sequences in the transcript were measured with complementary DNA copied from globin messenger RNA with RNA-dependent DNA polymerase. Globin messenger RNA sequences were found in RNA newly transcribed from chromatin from erythropoietic tissue but no...
متن کاملRemote control of gene transcription.
In this review, we look at the most recent studies of DNA elements that function over long genomic distances to regulate gene transcription and will discuss the mechanisms genes employ to overcome the positive and negative influences of their genomic neighbourhood in order to achieve accurate programmes of expression. Enhancer elements activate high levels of transcription of linked genes from ...
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Extensive studies during the last 30 years have led to considerable understanding of cellular and molecular control of hemoglobin switching. Cell biology studies in the 1970s defined the control of globin genes during erythroid differentiation and led to development of therapies for sickle cell disease. Molecular investigations of the last 20 years have delineated the two basic mechanisms that ...
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1Departamento de Genética, Facultad de Bioloǵıa, Universidad de Sevilla, Seville 41012, Spain 2Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, Shreveport, LA 71130-3932, USA 3Laboratoire de Genetique Moleculaire, Academie Universitaire Louvain, 5000 Namur, Belgium 4Departamento de Bioloǵıa Molecular, Instituto de Parasitoloǵıa y Biomedicina “...
متن کاملTranscription and Chromatin Organization of a Housekeeping Gene Cluster Containing an Integrated β-Globin Locus Control Region
The activity of locus control regions (LCR) has been correlated with chromatin decondensation, spreading of active chromatin marks, locus repositioning away from its chromosome territory (CT), increased association with transcription factories, and long-range interactions via chromatin looping. To investigate the relative importance of these events in the regulation of gene expression, we targe...
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ژورنال
عنوان ژورنال: Annual Review of Cell Biology
سال: 1990
ISSN: 0743-4634
DOI: 10.1146/annurev.cb.06.110190.000523